1. Home
    2. Journals
    3. Journal of Chemical Sciences
    4. Volume 134
    5. All articles

    • An expeditious and clean synthesis of novel benzotriazole-triazole conjugates via Copper-catalyzed Azide-Alkyne cycloaddition click protocol (CuAAC)

      Rashmi Sharma Anil Kumar

      Regular Article Volume 134 Published: 27 June 2022 Article ID 0069

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/134/0069

    • Keywords

       

      Benzotriazole alkynes; aryl azides; benzotriazole-triazole conjugates; Copper-catalysed azidealkyne cycloaddition.

    • Abstract

       

      A simple, efficacious, and regioselective synthesis of hitherto unreported benzotriazole-triazole conjugates via copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction between benzotriazole alkynes and aryl azides has been described. The structure of the synthesized molecules has been explicitly confirmed by spectroscopic analysis (1H NMR, 13C NMR, and mass spectroscopy).

    • Graphical Abstract

       

      This work describes a very simple, efficacious, and regioselective synthesis of hitherto unreported benzotriazole-triazole conjugates via copper-catalyzed azide-alkyne cycloaddition. The current protocol avoids the use of any reducing agent, which makes this protocol a better route for the synthesis of 1,4-disubstituted product.

    • Author Affiliations

       

      Rashmi Sharma Anil Kumar

      1. Dates

         
        Published
        27 June 2022
        Manuscript received
        10 March 2022
        Manuscript revised
        25 May 2022
        Accepted
        26 May 2022

      2. Supplementary Material

         

    • Journal of Chemical Sciences | News

    © 2022-2023 Indian Academy of Sciences, Bengaluru.

    Contact | Site index