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Fulltext
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Permanent link:
https://www.ias.ac.in/article/fulltext/jcsc/134/0056 -
Keywords
Selective α-aminoxylation ;Oxazolidinone class compounds ;Sutezolid ;Eperezolid. -
Abstract
The given article describes the synthesis of 2-Oxazolidinone ring via proline catalyzed stereoselective α-aminoxylation of aldehyde. 2-Oxazolidinone ring is a common core structure during the synthesis of oxazolidinones class molecules. Using this simple, facile and efficient methodology, Linezolid andsutezolid were prepared using asymmetric catalysis.
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Graphical Abstract
Selective α-aminoxylation was achieved on corresponding aldehyde with great enantiomeric excess to get intermediate (5) using catalytic amount of low cost proline. The oxazolidinone ring was then constructed on common intermediate (5) which was then further converted to Oxazolidinone class compounds like Sutezolid and Eperezolid.
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Author Affiliations
PANKAJ R CHAUDHARI1 NANDU B BHISE1 GIRIJ P SINGH1 VARADARAJ BHAT2 GAUTHAM G SHENOY2
- Chemical Research and Development, Lupin Limited, Mulshi, Pune, India
- Department of Chemistry, Manipal Academy of Higher education, Manipal, India
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Dates
- Published
- 20 April 2022
- Manuscript received
- 28 December 2021
- Manuscript revised
- 11 February 2022
- Accepted
- 6 March 2022
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Supplementary Material
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Journal of Chemical Sciences
Volume 135, 2023
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