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    • Eosin Y photocatalyzed access to Biginelli reaction using primary alcohols via domino multicomponent cascade: an approach towards sustainable synthesis of 3,4-dihydropyrimidin-2(1H)-ones

      GOBIND KUMAR GAURAV BHARGAVA YOGESH KUMAR RUPESH KUMAR

      Volume 134 Published: 15 March 2022 Article ID 0044

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/134/0044

    • Keywords

       

      Biginelli reaction; Photocatalysis; Eosin Y; 3,4-dihydropyrimidin-2(1H)-ones; Multicomponent reaction.

    • Abstract

       

      The Eosin Y photocatalyzed Biginelli protocol has been established by a cascade one-pot three-component reaction of primary alcohols, a-ketoester, and urea to provide pharmacologically promising 3,4-dihydropyrimidin-2(1H)-ones in high yields. The key benefits of the present scheme are the capability toallow operational simplicity, readily available substrates, straightforward workup and high yields. This EosinY based photocatalytic approach can permit conquering traditional metal-catalyzed reactions in a sustainablemanner, thus delivering economic and environmental rewards.

    • Graphical Abstract

       

      An environmentally benign protocol for the synthesis of 3,4-DHPMs has been developed using inexpensive molecular oxygen, visible light as green energy source and eosin Y as photoreceptor-cum-sensitizer. The utilized photoreceptor revealed its unique properties in rapid intersystem crossing, high photo and chemical stability, ease of separation and high catalytic efficiency.

    • Author Affiliations

       

      GOBIND KUMAR1 GAURAV BHARGAVA1 YOGESH KUMAR2 RUPESH KUMAR1

      1. Department of Chemical Sciences, I. K. G. Punjab Technical University, Kapurthala, Punjab 144603, India
      2. Department of Chemistry, Durham University, Durham DH1 3LE, UK

    • Dates

       
      Published
      15 March 2022
      Manuscript received
      14 October 2021
      Manuscript revised
      17 January 2022
      Accepted
      29 January 2022

    • Supplementary Material

       

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