• Eosin Y photocatalyzed access to Biginelli reaction using primary alcohols via domino multicomponent cascade: an approach towards sustainable synthesis of 3,4-dihydropyrimidin-2(1H)-ones

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    • Keywords


      Biginelli reaction; Photocatalysis; Eosin Y; 3,4-dihydropyrimidin-2(1H)-ones; Multicomponent reaction.

    • Abstract


      The Eosin Y photocatalyzed Biginelli protocol has been established by a cascade one-pot three-component reaction of primary alcohols, a-ketoester, and urea to provide pharmacologically promising 3,4-dihydropyrimidin-2(1H)-ones in high yields. The key benefits of the present scheme are the capability toallow operational simplicity, readily available substrates, straightforward workup and high yields. This EosinY based photocatalytic approach can permit conquering traditional metal-catalyzed reactions in a sustainablemanner, thus delivering economic and environmental rewards.

    • Graphical Abstract


      An environmentally benign protocol for the synthesis of 3,4-DHPMs has been developed using inexpensive molecular oxygen, visible light as green energy source and eosin Y as photoreceptor-cum-sensitizer. The utilized photoreceptor revealed its unique properties in rapid intersystem crossing, high photo and chemical stability, ease of separation and high catalytic efficiency.

    • Author Affiliations



      1. Department of Chemical Sciences, I. K. G. Punjab Technical University, Kapurthala, Punjab 144603, India
      2. Department of Chemistry, Durham University, Durham DH1 3LE, UK
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