A facile and efficient synthesis of Bis-thiazole from mono-thiazole
This paper describes a facile route for the synthesis of bis-thiazoles from mono-thiazole with aneco-friendly method. The synthetic procedure for the synthesis of bis-thiazoles from the reaction of 2-amino-4-tolyl thiazole with different aromatic aldehydes under microwave irradiations is discussed. Structures of thefinal products are characterized by IR, 1H and 13C- NMR spectra, DEPT-135 and mass spectrometry.
A facile method is developed to synthesis bis-amino thiazole from easily synthesised mono thiazole. A series of bis thiazole were obtained with free amino groups which can be used for late-stage synthesis of new bis heterocyclic compounds.
Volume 134, 2022
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