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Keywords
Pyrazine tetrazole ligand ;Microwave irradiation ;Cu(II) and Co(II) complexes ;Biological activities. -
Abstract
Two complexes, diaquabis[2-(1H-tetrazol-5-yl)pyrazinato]-Copper(II) (1) and Cobalt (II)(2), aresynthesized by microwave irradiation. These complexes are characterized by IR, PXRD, SEM-EDX, andTGA-DTG studies. Single crystal studies of complex 1 are carried out to reveal its octahedral structure.Hirshfield analysis is conducted to show the hydrogen bonding interactions. TGA\DTG data revealed that thecompounds decompose in three stages at 600°C. The complexes exhibited photocatalytic activity bydegrading methyl orange, methylene blue, and congo red dyes. The synthesized compounds were evaluatedfor their biological potentials against DNA binding studies on calf thymus, DNA Cleavage activity onpBR322 plasmid DNA in the absence and presence of H2O2. Anti-bacterial activity is shown by both the complexes. Molecular docking is done to show the effective inhibition of bacterial proteins.
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Graphical Abstract
In this paper, we present two complexes, diaquabis [2-(1H-tetrazol-5-yl) pyrazinato]-Copper (II) (1) and Cobalt (II) (2), synthesized by microwave activation. They are characterized by spectral methods to confirm their structure. The complexes also degrade the dyes in the presence of UV. The complexes bind well to ct-DNA, cleave DNA, and exhibited anti-bacterial activity. Molecular docking is performed to show the effective inhibition of bacterial proteins.
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Author Affiliations
RAMA DEVI GUTTA1 ABDUL RAJACK2 SATYA VENI SUNKARA1 RAJA KARREDDULA3 GOPI P KRISHNA4 SURENDRA BABU MANABOLU SURYA5
- Department of Chemistry, Jawaharlal Nehru Technological University Kakinada, Kakinada, India
- Department of Chemistry, MVGR College of Engineering, Vizianagaram, India
- Department of Chemistry, Rajeev Gandhi Memorial College of Engineering and Technology (Autonomous), Andhra Pradesh State, Kurnool dist, Nandyal, India
- Department of Zoology, Vikramshimapuri University, Kavali, Nellore Dist, Andhra Pradesh, India
- Department of Chemistry, School of Science, GITAM Deemed to be University, Hyderabad, India
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Dates
- Published
- 21 February 2022
- Manuscript received
- 25 September 2021
- Manuscript revised
- 22 November 2021
- Accepted
- 23 November 2021
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Journal of Chemical Sciences
Volume 135, 2023
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