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      https://www.ias.ac.in/article/fulltext/jcsc/134/0026

    • Keywords

       

      Cucurbit[8]uril; sulfanilamide; sulfamethoxazole; crystal structure; supramolecular selfassembly

    • Abstract

       

      In this study, cucurbit[8]uril (Q[8]) was used as a carrier for Sulfanilamide (G1) and sulfamethoxazole (G2), and the crystals of their inclusion complexes were cultured in a 3M HCl aqueoussolution upon the addition of ZnCl2 as an inducer. The crystal structure was characterized using single-crystal X-ray diffraction. The results showed that two new supramolecular self-assemblies were constructed and themain driving forces in the system were hydrogen bond and ion–dipole interactions. In addition, the effects ofQ[8] on the solubility and cumulative release rate in vitro of G1 and G2 were investigated by UV Visspectroscopy. The results showed that the intervention of Q[8] had no effect on the solubility of G1 and G2;the cumulative release rates of G1 and G2 in artificial gastrointestinal juice were reduced and had a certainsustained-release effect.

    • Graphical Abstract

       

      In this study, we reported that Cucurbit[8]uril (Q[8]) was used as the carrier of P-aminobenzenesulfonamide and sulfamethoxazole. The experimental results show that the main driving forces of the system are hydrogen bond and ion-dipole interaction and two new supramolecular self-assemblers were constructed.

    • Author Affiliations

       

      LIN ZHANG1 JUN ZHENG1 ZHISHU ZENG1 GUANGYAN LUO1 XIAOYUE LI1 QIANJUN ZHANG1

      1. Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, College of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, P. R. China
    • Dates

       
  • Journal of Chemical Sciences | News

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