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Permanent link:
https://www.ias.ac.in/article/fulltext/jcsc/134/0026 -
Keywords
Cucurbit[8]uril ;sulfanilamide ;sulfamethoxazole ;crystal structure ;supramolecular selfassembly -
Abstract
In this study, cucurbit[8]uril (Q[8]) was used as a carrier for Sulfanilamide (G1) and sulfamethoxazole (G2), and the crystals of their inclusion complexes were cultured in a 3M HCl aqueoussolution upon the addition of ZnCl2 as an inducer. The crystal structure was characterized using single-crystal X-ray diffraction. The results showed that two new supramolecular self-assemblies were constructed and themain driving forces in the system were hydrogen bond and ion–dipole interactions. In addition, the effects ofQ[8] on the solubility and cumulative release rate in vitro of G1 and G2 were investigated by UV Visspectroscopy. The results showed that the intervention of Q[8] had no effect on the solubility of G1 and G2;the cumulative release rates of G1 and G2 in artificial gastrointestinal juice were reduced and had a certainsustained-release effect.
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Graphical Abstract
In this study, we reported that Cucurbit[8]uril (Q[8]) was used as the carrier of P-aminobenzenesulfonamide and sulfamethoxazole. The experimental results show that the main driving forces of the system are hydrogen bond and ion-dipole interaction and two new supramolecular self-assemblers were constructed.
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Author Affiliations
LIN ZHANG1 JUN ZHENG1 ZHISHU ZENG1 GUANGYAN LUO1 XIAOYUE LI1 QIANJUN ZHANG1
- Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, College of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, P. R. China
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Dates
- Published
- 5 February 2022
- Manuscript received
- 5 May 2021
- Manuscript revised
- 18 October 2021
- Accepted
- 25 October 2021
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Journal of Chemical Sciences
Volume 135, 2023
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