In this study, cucurbituril (Q) was used as a carrier for Sulfanilamide (G1) and sulfamethoxazole (G2), and the crystals of their inclusion complexes were cultured in a 3M HCl aqueoussolution upon the addition of ZnCl2 as an inducer. The crystal structure was characterized using single-crystal X-ray diffraction. The results showed that two new supramolecular self-assemblies were constructed and themain driving forces in the system were hydrogen bond and ion–dipole interactions. In addition, the effects ofQ on the solubility and cumulative release rate in vitro of G1 and G2 were investigated by UV Visspectroscopy. The results showed that the intervention of Q had no effect on the solubility of G1 and G2;the cumulative release rates of G1 and G2 in artificial gastrointestinal juice were reduced and had a certainsustained-release effect.
In this study, we reported that Cucurbituril (Q) was used as the carrier of P-aminobenzenesulfonamide and sulfamethoxazole. The experimental results show that the main driving forces of the system are hydrogen bond and ion-dipole interaction and two new supramolecular self-assemblers were constructed.
Volume 135, 2023
Continuous Article Publishing mode
Click here for Editorial Note on CAP Mode