2-Aminopyridine Cadmium (II) meso-chlorophenylporphyrin coordination compound. Photophysical properties, X-ray molecular structure, antimicrobial activity, and molecular docking analysis
CHADLIA MCHIRI HAYET EDZIRI HALIMA HAJJI MOHAMMED BOUACHRINE SAMIR ACHERAR CE´LINE FROCHOT HANAN O BADR ELDINE SANA BEN MOUSSA HABIB NASRI
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The reaction of the [meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II) complex ([Cd(TClPP)]) with an excess of 2-aminopyridine results in the formation of the corresponding axially ligated(2- aminopyridine)[meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II)with the formula [Cd(TClPP)(2-NH2Py)] (I). This five-coordinated metalloporphyrin was characterized by infrared, UV-visible, fluorescence,singlet oxygen, 1H nuclear magnetic resonance and single crystal X-ray diffraction techniques. The in vitro antimicrobial activity of the free base porphyrin H2TClPP porphyrin, the [Cd(TClPP)] starting material andcomplex (I) were screened against different species of bacteria. The assays showed an increase of antimicrobial potential due to the insertion of the cadmium metal into the H2TClPP porphyrin and the axial coordination of 2-aminopyridine. Molecular docking approach indicated that [Cd(TClPP)(2-NH2Py)] hashigher binding affinity with hydrogen-bonding interactions.
2-aminopyridine Cadmium(II) meso-chlorophenylporphyrin coordination compound abbreviated as [Cd(TClPP)(2-NH2Py)] was synthesized and characterized. This compound shows interesting antibacterial properties. The molecular docking approach suggests that [Cd(TClPP)(2-NH2Py)] has higher binding affinity with hydrogen bonding interactions.
CHADLIA MCHIRI1 HAYET EDZIRI2 HALIMA HAJJI3 MOHAMMED BOUACHRINE3 4 5 SAMIR ACHERAR3 4 5 CE´LINE FROCHOT6 HANAN O BADR ELDINE7 SANA BEN MOUSSA7 HABIB NASRI1
Volume 135, 2023
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