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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/134/0022

    • Keywords

       

      Cadmium porphyrin; 2-aminopyridine ligand; Photophysical properties; Antimicrobial activity; Molecular docking.

    • Abstract

       

      The reaction of the [meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II) complex ([Cd(TClPP)]) with an excess of 2-aminopyridine results in the formation of the corresponding axially ligated(2- aminopyridine)[meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II)with the formula [Cd(TClPP)(2-NH2Py)] (I). This five-coordinated metalloporphyrin was characterized by infrared, UV-visible, fluorescence,singlet oxygen, 1H nuclear magnetic resonance and single crystal X-ray diffraction techniques. The in vitro antimicrobial activity of the free base porphyrin H2TClPP porphyrin, the [Cd(TClPP)] starting material andcomplex (I) were screened against different species of bacteria. The assays showed an increase of antimicrobial potential due to the insertion of the cadmium metal into the H2TClPP porphyrin and the axial coordination of 2-aminopyridine. Molecular docking approach indicated that [Cd(TClPP)(2-NH2Py)] hashigher binding affinity with hydrogen-bonding interactions.

    • Graphical Abstract

       

      2-aminopyridine Cadmium(II) meso-chlorophenylporphyrin coordination compound abbreviated as [Cd(TClPP)(2-NH2Py)] was synthesized and characterized. This compound shows interesting antibacterial properties. The molecular docking approach suggests that [Cd(TClPP)(2-NH2Py)] has higher binding affinity with hydrogen bonding interactions.

    • Author Affiliations

       

      CHADLIA MCHIRI1 HAYET EDZIRI2 HALIMA HAJJI3 MOHAMMED BOUACHRINE3 4 5 SAMIR ACHERAR3 4 5 CE´LINE FROCHOT6 HANAN O BADR ELDINE7 SANA BEN MOUSSA7 HABIB NASRI1

      1. Laboratoire de Physico-Chimie des Mate´riaux (LPCM), Faculte´ des Sciences de Monastir, University of Monastir, Avenue de l’Environnement, 5019 Monastir, Tunisia
      2. Laboratory of Analyzes of Treatment and Valuation of Environmental Products, High Institut of Biotechnology of Monastir, University of Monastir, 5019 Monastir, Tunisia
      3. MCNS Laboratory, Faculty of Science, Moulay Ismail University, Meknes, Morocco
      4. EST Khenifra, Sultane Moulay Sliman University, Khenifra, Morocco
      5. Laboratoire de Chimie Physique Macromole´culaire (LCPM), Universite´ de Lorraine, CNRS, 1 rue Grandville BP 20451, 54001 Nancy Cedex, France
      6. Laboratoire Re´actions et Ge´nie des Proce´de´s (LRGP), Universite´ de Lorraine, CNRS, 1 rue Grandville BP 20451, 54001 Nancy Cedex, France
      7. Faculty of Science and arts, King Khalid University, Mohail Asser, Saudi Arabia

    • Dates

       
      Published
      4 February 2022
      Manuscript received
      5 August 2021
      Manuscript revised
      15 November 2021
      Accepted
      17 November 2021

    • Supplementary Material

       

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