Molecularly imprinted polymers of triphenylphosphine oxide (MIPs-TPPO) were synthesizedand evaluated for use as a solid scavenger to remove triphenylphosphine oxide from reaction mixtures, abyproduct commonly formed during organic synthesis reactions involving triphenylphosphine (PPh₃) reagent.The efficiency of synthesized polymers was initially investigated using a variety of functional monomers andcross-linkers. Precipitation polymerization in acetonitrile was carried out at 80° C for 6 h with benzoylperoxide as an initiator, then template removal with dichloromethane. The MIPs-TPPOs affinity was evaluated by rebinding study with template molecule; additionally, the effect of binding time, selectivity, andreusability of synthesized MIPs-TPPOs were investigated. From the results, polymers containing styrene as afunctional monomer and ethyleneglycol dimethacrylate as a cross-linker demonstrated the highest performance (86.00%Bound) after only 1 h. Moreover, the selected MIPs-TPPO can be reused at least five times,and this selective material can act as a solid scavenger of triphenylphosphine oxide.