• Pyruvic acid-catalyzed one-pot three-component green synthesis of isoxazoles in aqueous medium: a comparable study of conventional heating versus ultra-sonication

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    • Keywords

       

      4H-isoxazol-5-one; pyruvic acid; aldehyde; ultrasound irradiation; green chemistry; multicomponent reaction (MCR).

    • Abstract

       

      A mild and efficient route for the one-pot synthesis of isoxazole derivatives has been developedusing pyruvic acid as a catalyst under an aqueous medium. The reaction was carried out under conventional aswell as ultrasonic conditions to afford the desired product in good yield. The features of this protocol are theuse of environmental-friendly, commercially available, biodegradable catalyst, use of biologically safe solvent, simple experimental procedure and short reaction times. The given protocol can be a better alternativefor the synthesis of 4H-isoxazol-5-one derivatives as compared to traditional methods.

    • Graphical Abstract

       

      Synopsis: A mild and efficient route for the one pot synthesis of isoxazole derivatives has been developed using pyruvic acid as a catalyst under aqueous medium. The reaction was carried out under conventional as well as ultrasonic condition to afford the desired product in good yield.

    • Author Affiliations

       

      SANTOSH R DESHMUKH1 ARCHANA S NALKAR2 SHANKAR R THOPATE2

      1. Prof. John Barnabas Post Graduate School for Biological Studies, Department of Chemistry, Ahmednagar College, Ahmednagar, Maharashtra 414001, India
      2. Department of Chemistry, Shri Sadguru Gangageer Maharaj Science, Gautam Arts and Sanjivani Commerce College, Kopargaon, Maharashtra 423601, India
    • Dates

       
  • Journal of Chemical Sciences | News

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