The activation of the C-F bond in 1-fluorobutane, 1, 1-difluorobutane and 1, 1, 1-trifluorobutaneby some frustrated Lewis pair (FLP) has been assessed by DFT based computational study. The FLPs areconstructed from lutidine Lewis base in association with either B(C₆F₅)₃ or Al(C₆F₅)₃. Thermodynamics andkinetics of the reactions are studied, which reveals the concerning bond activation mediated by the Al(C₆-F₅)₃/lutidine FLP is more favourable than the analogous reactions mediated by the B(C₆F₅)₃/lutidine pair.Therefore, the Al(C₆F₅)₃ acid is superior to the B(C₆F₅)₃ acid to construct an effective FLP for some unusualbond activation. The EDA-NOCV study together with the WBI calculation reveals the C-F bond activation inthe studied systems takes place by the cooperative action of the FLP partners. The activation strain modelreveals the strain energy of the reactants to reach the transition state (TS) rather than the interaction energy atthe TS is the decisive factor to the TS barrier height of the concerned reactions.