N-(5-acetyl-4-methylthiazol-2-yl)arylamide derivatives as multitarget- directed ligands: design, synthesis, biochemical evaluation and computational analysis
In the present study, we are reporting the synthesis of a total eight derivatives of N-(5-acetyl-4-methylthiazol-2-yl) Arylamide derivatives (3a-h). The products obtained in good to excellent yield representsdrug-like molecules with a well-developed structure-activity relationship. All the synthesized compoundswere further subjected to chemical characterization (NMR, FTIR and elemental analysis) and further testedfor biological activities (antioxidant, antibacterial, antifungal and α-glucosidase). The anti-oxidant propertiesof compound 3h (IC50 ± SEM = 141.9 ± 1.12 μg/mL) were found maximum in comparison to the rest of thederivatives. The antibacterial results showed the compounds 3d and 3h as a significant bacterial inhibitor. Thesignificant fungicidal activity was observed by compound 3a with the zone of inhibition up to 24 mm whichin comparison with the results of positive control (Terbinafine). When the effect was observed on α-glucosidaseactivity, the highest enzyme inhibition activity was observed by 3h (IC50 ± SEM 134.4 ± 1.01 lμ/mL) followed by 3c (IC50 ± SEM = 157.3 ± 1.11 lμ/mL). The results were further supported by moleculardocking studies and the chemical stability of the derivatives was also performed by density functional theory(DFTs) calculations. The data revealed that most of the derivatives are multi-target ligands and can be used aslead molecules for the synthesis of derivatives for their further evaluation at molecular targets for thetreatment of specific diseases.
Synopsis This article reports the synthesis of a total of eight derivatives of N-(5-acetyl-4-methylthiazol-2-yl) Arylamide derivatives. The products obtained in good to excellent yield represents drug-like molecules with a well-developed structure-activity relationship.
Volume 134, 2022
Continuous Article Publishing mode
Click here for Editorial Note on CAP Mode