• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/133/0107

    • Keywords

       

      Thiocarbohydrazone; copper(II) complexes; fluorescence; crystal structure; DNA cleavage.

    • Abstract

       

      Two Schiff base ligands FT1 and FT2 and their Cu(II) complexes were synthesized and characterizedby 1H NMR, ESI-MS, IR, UV-Visible, Fluorescence spectroscopy, EPR and single-crystal X-raydiffraction studies. FT1 crystallizes in the triclinic system while FT2 in the orthorhombic. The DNA cleavageactivity of Cu(II) complexes was studied using plasmid pBR322 DNA by gel electrophoresis. All compoundscleave DNA on photoirradiation by oxidative mechanism.

    • Graphical Abstract

       

      Two Schiff base ligands FT1 and FT2 and their Cu(II) complexes were synthesized and characterized by 1H NMR, ESI-MS, IR, UV-Visible, Fluorescence spectroscopy, EPR and single-crystal X-ray diffraction studies. Both the Cu(II) complexes of indole thiocarbohydrazones are shown to cleave plasmid pBR322 DNA by oxidative mechanism.

    • Author Affiliations

       

      SHRIDHAR PAWAR1 ANITA AMATE1 DEBAMITRA CHAKRAVARTY1 RAYMOND J BUTCHER2 ANUPA A KUMBHAR1

      1. Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India
      2. Department of Chemistry, Howard University, 2400 Sixth Street NW, Washington, DC 20059, USA
    • Dates

       
  • Journal of Chemical Sciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.