• Highly efficient aqueous-phase Sonogashira coupling catalyzed by Pd-PEEPSI/PPh3 under aerobic condition

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      https://www.ias.ac.in/article/fulltext/jcsc/133/0103

    • Keywords

       

      Cross-coupling; carbene ligands; palladium; PEPPSI; sonogashira reaction.

    • Abstract

       

      An in situ generated catalytic system comprised of a Pd-PEPPSI [Pyridine enhanced pre-catalystpreparation, initiation, and stabilization] complex, (NHC)PdBr2(Pyridine), and PPh3 co-ligand demonstratedexcellent activity for the Sonogashira cross-coupling reactions between phenylacetylene with aryl halides inneat water under the aerobic condition in presence of CuI as co-catalyst. The catalytic system was not onlycompatible with electronically diverse aryl bromides/ iodides but also effective for relatively difficult substrateslike heteroaryl bromides. Notably, under similar experimental conditions, the mixed PEPPSI/PPh3system displayed superior activity over the free Pd-PEPPSI or Pd-phosphine system.

    • Graphical Abstract

       

      This article presents an in situ Pd-PEPPSI/PPh3 catalytic system for aqueous Sonogashira reaction in presence of CuI under aerobic condition which was found to be highly efficient for coupling of anyl/heteroaryl halides with phenylacetylene to form substituted alkynes. Interestingly, it displayed superior activity over simple Pd-PEPPSI or Pd-PPh3 catalysts

    • Author Affiliations

       

      DHRUBAJIT BORAH1 2 AMLAN PUZARI1 PANKAJ DAS1

      1. Department of Chemistry, Dibrugarh University, Dibrugarh, Assam 786004, India
      2. Department of Chemistry, N. N. Saikia College, Titabar, Assam 785630, India
    • Dates

       
  • Journal of Chemical Sciences | News

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