• Supramolecular conjugates of calixarenes in biological cells by microscopy

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      https://www.ias.ac.in/article/fulltext/jcsc/133/0092

    • Keywords

       

      Conjugates of calixarene; morphological features; microscopy; biological cells; AFM; SEM; LSM.

    • Abstract

       

      During the past two decades, the supramolecular conjugates of calixarenes have turned intriguingto the researchers due to their versatility in functionalization and applications spanning across various fields,such as chemical, biological and materials sciences. Though several review articles discuss host-guest andother functional aspects of the supramolecular conjugates of calixarenes, there is no such article that consolidates the role of the conjugates in the context of cell science. In this article, we focus on the utility of suchconjugates in the biological cells as studied primarily using microscopy techniques that include endeavoursemerging from our research group. Therefore, this will assist researchers working in this area in order tounderstand the microscopy aspects of calixarene based supramolecular conjugates inside the biological cellsand thereby support the design of newer conjugates planned to target a specific purpose. Thus, this articlefocuses on the aspects, such as drug loading and bactericidal activity, gene transfer, selective ion sensing, andcell imaging by localizing in mitochondria, cytosol or Golgi apparatus, i.e., in any one of the subcellularcomponents.

    • Graphical Abstract

       

      Synopsis Supramolecular conjugates of calixarenes turned intriguing to the researchers due to their versatility in functionalization and in exhibiting diverse applications. This article focusses on the microscopy data for drug loading, bactericidal activity, gene transfer, ion sensing and cell imaging and thereby support the design of newer conjugates to target specific purposes.

    • Author Affiliations

       

      RAHUL NAG PULLA RAO CHEBROLU1

      1. Department of Chemistry, Indian Institute of Technology Tirupati, Settipalli Post, Tirupati, Andhra Pradesh 517506, India
    • Dates

       
  • Journal of Chemical Sciences | News

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