This work presents two mononuclear Zn(II) complexes of amide-based pincer ligands wheremigration of protons from the amidic N–H groups to the appended heterocyclic rings resulted in theirprotonation. The crystal structures of both the zinc complexes illustrated that such protonated heterocyclicrings created an H-bonding based secondary coordination sphere. Both complexes were utilized for theselective detection of fluoroquinolone antibiotics ciprofloxacin and norfloxacin. The two complexes exhibitedhigh selectivity for norfloxacin with nanomolar detection limits of 290 and 460. The binding studies werefurther supported with the NMR spectroscopic and the molecular docking studies that exhibited that anantibiotic interacts with a zinc complex that was responsible for its emission enhancement based detection.
Synopsis This work presents two structurally characterized zinc complexes of amide-based ligands and their role in the selective detection of fluoroquinolone antibiotics ciprofloxacin and norfloxacin.
Volume 133, 2021
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