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      https://www.ias.ac.in/article/fulltext/jcsc/133/0085

    • Keywords

       

      Cyanide selective sensor; Dihydrazide; 2-hydroxy-1-naphthaldehyde; Colorimetric and fluorimetric sensor; Live cell imaging.

    • Abstract

       

      In the present study, the Schiff based compound (N′1E,N′3E)-N′1, N′3-bis((2-hydroxynaphthalen-1-yl)methylene)malonohydrazide (1) is synthesized via a facile method, characterized and furtherinvestigated for CN- sensing. Compound 1 is synthesized by the reaction of malonyldihydrazide and2-hydroxy-1-naphthaldehyde and its characterization is performed by FT-IR, 1H NMR and ESI-MS spectrometry.Absorption spectrum pattern of 1 is altered upon the addition of CN- ion selectively with thegeneration of a new band at 416 nm in H2O-DMSO (8:2 v/v) medium. The detection limit of 1 for CN- ion isassessed using UV-visible spectral data which is found to be 36.3 μM. The selective visual colour change isobserved upon the addition of CN- ion to colourless solution of 1 (colourless to yellow). A similar change incolour is also detected on Whatman filter paper test strips. Fluorescence intensity of sensor 1 is found to beenhanced on the addition of CN- ion. 1H NMR titration of 1 with CN- ion corroborates the binding of theformer using its naphthol OH and NH protons with the latter. Sensor 1 is also evaluated for intracellulardetection of CN- ion in A549 cells.

    • Graphical Abstract

       

      Synopsis Compound 1 behaves as colorimetric and fluorimetic sensor for CN selectively in solution and on Whatman filter paper test strips. Binding of CN by 1 is supported by 1H NMR titration. Sensor 1 acts as an imaging reagent for live cell intra-cellular detection of CN in A549 cells.

    • Author Affiliations

       

      ASHISH RAINA1 KOMAL KUMAR YADAV1 YADVENDRA SINGH2 TAMAL GHOSH1

      1. Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad, Prayagraj 211 004, India
      2. Department of Chemistry, University of Allahabad, Prayagraj 211 002, India
    • Dates

       
  • Journal of Chemical Sciences | News

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