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    • Keywords

       

      Speciation of Ni2+; kinetics and mechanism; hydrogen bonding; 5,10,15,20-tetrakis(Nmethylpyridium- 4-yl)porphyrinatonickel(II) tetracation; outside binding; chemotherapeutic agents.

    • Abstract

       

      Kinetics between 5,10,15,20-tetrakis(N-methylpyridium-4-yl)porphyrin and Ni2+ species wereinvestigated in aqueous solution at 25 ±1 °C in I = 0.10 M (NaNO3). Speciation of Ni2+ was done in I = 0.10M (NaNO3) for knowing distribution of Ni2+ species with solution pH. Experimental data were comparedwith speciation diagram constructed from the values of hydrolysis constants of Ni2+ ion. Speciation datashowed that hexaaquanickel(II) ions took place in hydrolysis reactions through formation of [Ni(OH2)6-n(OH)n]2-n species with solution pH. According to speciation of Ni2+ and pH dependent rate constants, rateexpression can be written as: d[Ni(TMPyP)4+]/dt = (k1[Ni2+(aq)] + k2[Ni(OH)+(aq)] + k3[Ni(OH)2o(aq)] + k4[Ni(OH)3-(aq)])[H2TMPyP4+], where k1, k2, k3 and k4 were found to be k1 = (0.62 ± 0.22) ˟ 10-2; k2 = (3.60± 0.40) ˟ 10-2; k3 = (2.09 ± 0.52) ˟ 10-2, k4 = (0.53 ± 0.04) ˟ 10-2 M-1s-1 at 25 ±1 °C, respectively.Formation of hydrogen bonding between [Ni(H2O)5(OH)]+ and [H2TMPyP]4+ causes enhanced reactivity.Rate of formation of [Ni(II)TMPyP]4+ complex was to be 3.99 ˟ 10-2 M-1s-1 in I = 0.10 M, NaNO3 (25 ±1 °C). UV-Vis and fluorescence data suggested that [Ni(II)TMPyP]4+ and [H2(TMPyP)]4+ interact with DNA via outside binding with self-stacking and intercalation, respectively.

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    • Author Affiliations

       

      AHSAN HABIB1 SALMA SERNIABAD1 2 MOHAMMAD SHAMIM KHAN1 ROKAYEA ISLAM1 MRITTIKA CHAKRABORTY1 AKLIMA NARGIS1 MD EMRAN QUAYUM1 MD ASHRAFUL ALAM2 VALENTINA RAPOZZI3 MASAAKI TABATA4

      1. Department of Chemistry, Faculty of Science, University of Dhaka, Dhaka 1000, Bangladesh
      2. Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali 3814, Bangladesh
      3. Department of Medicine, Udine University, P.le Kolbe 4, 33100 Udine, Italy
      4. Department of Chemistry, Faculty of Science and Engineering, Saga University, 1, Honjo-machi, Saga 840-8502, Japan
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  • Journal of Chemical Sciences | News

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