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      https://www.ias.ac.in/article/fulltext/jcsc/133/0072

    • Keywords

       

      2-Iodonaphthalene; Gold Cluster; Excimer; Fluorescence; Thiol.

    • Abstract

       

      Here we report fluorescence quenching based detection of selected ‘‘Thiol’’ molecules byemploying a luminescent gold cluster through ligand displacement strategy. First, an aryl iodide (2-Iodonaphthalene,NP) and polyvinylpyrrolidone (PVP) mixed ligand stabilized gold cluster was synthesized with astrong fluorescence signal originated from excimer of 2-Iodonaphthalene ligands grafted on gold nano surface.Among different small molecule-based ligands, thiol (R-SH) forms a strong bond with gold nanoparticles.Anticipating this property, we have found that displacement of 2-Iodonaphthalene ligand from goldnanoparticle surface by thiols results in the sensitive detection of thiols through the quenching of emission ofgold cluster. The selectivity for detection of different tested analytes follows the order: GSH>Cys>hCywhereas, other non-thiol based amino acids and common salts are innocent towards fluorescence response.Easy synthesis of the fluorescent gold cluster, selective sensing of small thiol molecules, high Stern-Volmerconstant (KSV=3.3×106 M-1) and ultralow detection limit (LOD of 35 nM) are notable features of the presentreport.

    • Graphical Abstract

       

      A fluorescence turn-off chemosensor has been developed for sensing selected ‘thiol’ molecules by employing 2-Iodonaphthalene and polyvinylpyrrolidone (PVP) mixed ligand stabilized luminescent gold cluster through ligand displacement strategy.

    • Author Affiliations

       

      JASMIN KUBAVAT1 2 JAYDEV THAKARDA1 TUSHAR TYAGI1 SAGAR BHOWMIK1 PRASENJIT MAITY1

      1. School of Engineering and Technology, National Forensic Sciences University, Sector-09, Gandhinagar 382007, India
      2. School of Pharmacy, National Forensic Sciences University, Sector-09, Gandhinagar 382007, India
    • Dates

       
  • Journal of Chemical Sciences | News

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