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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/133/0069

    • Keywords

       

      Pyrazole-4-carbaldehyde; pyrazole-4-carbonitrile; H3PO4; formic acid.

    • Abstract

       

      One-pot condensation of pyrazole-4-aldehydes and hydroxylamine hydrochloride to form thecorresponding oxime using formic acid as a medium and further dehydration of oxime using a catalyticamount of orthophosphoric acid to afford novel pyrazole-4-carbonitrile. This protocol serves as an orthophosphoricacid-catalyzed one-pot conversion of aldehyde to nitrile. Most remarkable features of this methodare metal-free, cost-effective, atom efficiency with excellent yield (98–99%). This process will serve as arobust and scalable tool for the synthesis of valuable and versatile precursor (nitriles). This precursor willpave the way for the synthesis of various medicinally important valuable compounds.

    • Graphical Abstract

       

    • Author Affiliations

       

      TUKARAM S CHOUDHARE1 DEVENDRA S WAGARE2 SAGAR E SHIRSATH3 PRASHANT D NETANKAR1

      1. Department of Chemistry, Maulana Azad College, Aurangabad 431 004, India
      2. Department of Chemistry, Vivekanand Arts, Sardar Dalipsingh Commerce and Science College, Auranagbad 43002, India
      3. School of Materials Science and Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia

    • Dates

       
      Published
      2 July 2021
      Manuscript received
      20 February 2021
      Manuscript revised
      11 May 2021
      Accepted
      11 May 2021

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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