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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/133/0048

    • Keywords

       

      Tafamidis; synthesis; reductive Cyclisation; zinc-MsOH; 2-aryl benzoxazoles.

    • Abstract

       

      A practical zinc-MsOH mediated intra-molecular reductive cyclisation and its application in thesynthesis of tafamidis is presented starting from the readily available 3-hydroxy-4-nitrobenzoic acid as aprecursor. The key reductive cyclization step involves the use of a combination of the readily available zincand MsOH as the catalyst system. This methodology provides an attractive route to 2-aryl benzoxazoles from

      ortho-nitro phenols under mild reaction conditions. This methodology is developed on a multi-gram scale andwithout the need for column chromatography.

    • Graphical Abstract

       

      A new and alternative zinc-MsOH mediated intra-molecular reductive cyclisation and its application in the synthesis of tafamidis is reported starting from the readily available 3-hydroxy-4-nitrobenzoic acid as precursor. This method provides an attractive route to 2-aryl benzoxazoles from ortho-nitro phenols under mild reaction conditions.

    • Author Affiliations

       

      KISHORE KARUMANCHI1 SENTHIL KUMAR NATARAJAN SUNIL GADDE KRISHNA VANCHANAGIRI KRISHNAMURTHY V R MOTURU

      1. Chemical Research Department, APL Research Centre-II, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran Village, Kandi Mandal, Sangareddy District 502329, Telangana State, India
    • Dates

       
  • Journal of Chemical Sciences | News

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