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Permanent link:
https://www.ias.ac.in/article/fulltext/jcsc/133/0047 -
Keywords
Bromomethylcoumarin ;Cyclopropane ;KSCN ;K2CO3 ;Aryl/hetrocyclic aldehydes and activemethylenes. -
Abstract
A novel and efficient one-pot method has been developed for the synthesis of cyclopropanes by the cyclization of 4-bromomethylcoumrains, benzaldehydes and active methylene groups in 1:1 acetonitrile and water solvent in the presence of KSCN and K2CO3 as a catalyst at room temperature for 2-5 h. The significant attraction of this procedure is environmentally benign, simple procedure, the ready accessibility of the catalyst, excellent yield and mild reaction conditions. The structure of the target molecule (4b) was confirmed by X-ray diffraction.
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Graphical Abstract
Synopsis: A library of novel cyclopropanyl coumarin derivatives were synthesised in good yields through one-pot three-component cyclization of 4-bromomethylcoumarins, benzaldehydes and active methylene groups. The structures of the synthesised compounds were confirmed by spectral methods viz. IR, 1H NMR, 13C NMR, mass spectral analysis and X-ray diffraction studies.
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Author Affiliations
MOHAMMED IMRANKHAN KALEGOWDA SHIVASHANKAR1
- Department of Chemistry, Central College Campus, Bangalore University, Bangalore, Karnataka, India
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Dates
- Published
- 30 April 2021
- Manuscript received
- 18 August 2020
- Manuscript revised
- 2 December 2020
- Accepted
- 24 February 2021
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Journal of Chemical Sciences
Volume 135, 2023
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