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      https://www.ias.ac.in/article/fulltext/jcsc/133/0045

    • Keywords

       

      Transition metals; thiosemicarbazone complexes; X-ray structure; anticancer activity.

    • Abstract

       

      Thiosemicarbazone metal complexes [Cu(L)(2-benzpy)]ClO4 (1) and [Zn(L)2] (2) [L = 2-benzoylpyridine-N(4)-methyl-3-thiosemicarbazone), 2-benzpy = 2-benzolylpyridine] were synthesized and X-raycrystallographically characterized. The metal centre in compound 1 has a distorted square planar geometry while in compound 2, the metal centre has a distorted octahedral geometry. Both the molecules induce cytotoxic effects on A431 skin carcinoma cell line in 24 h incubation and significantly enhances hypoploid cell population in cell cycle phase distribution below IC50 dose. Application of both the two molecules exhibit apoptotic induction and genotoxic activity in 24 h exposure.

    • Graphical Abstract

       

    • Author Affiliations

       

      CHINMOY BISWAS1 ARNAB CHATTERJEE1 SONALI BHATTACHARYA2 DEBA PRASAD MANDAL2 SHAMEE BHATTACHARJEE2 RAJARSHI GHOSH1

      1. Department of Chemistry, The University of Burdwan, Burdwan 713 104, West Bengal, India
      2. Department of Zoology, West Bengal State University, Barasat, Kolkata 700 126, West Bengal, India
    • Dates

       
  • Journal of Chemical Sciences | News

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