T2- and T1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes
ALEXEY STEPANOV SVETLANA FEDORENKO RAFAEL MENDES MARK RU¨ MMELI LARS GIEBELER BRUNO WEISE THOMAS GEMMING SILVIO DUTZ DIANA ZAHN ILDUS ISMAEV RUSTEM AMIROV KIRILL KHOLIN ALEXANDRA VOLOSHINA ANASTASIYA SAPUNOVA SVETLANA SOLOVIEVA ASIYA MUSTAFINA
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The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8±2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1±14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM-1 s-1, respectively) at 1.5 T and 25 °C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia.
ALEXEY STEPANOV1 SVETLANA FEDORENKO1 RAFAEL MENDES2 MARK RU¨ MMELI2 3 4 5 LARS GIEBELER2 BRUNO WEISE2 THOMAS GEMMING2 SILVIO DUTZ6 DIANA ZAHN6 ILDUS ISMAEV7 RUSTEM AMIROV8 KIRILL KHOLIN1 ALEXANDRA VOLOSHINA1 ANASTASIYA SAPUNOVA1 SVETLANA SOLOVIEVA1 ASIYA MUSTAFINA1
Volume 135, 2023
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