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      https://www.ias.ac.in/article/fulltext/jcsc/133/0043

    • Keywords

       

      Gd complexes; Iron-oxide nanoparticles; Magnetic resonance imaging; Hyperthermia.

    • Abstract

       

      The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8±2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1±14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM-1 s-1, respectively) at 1.5 T and 25 °C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia.

    • Graphical Abstract

       

    • Author Affiliations

       

      ALEXEY STEPANOV1 SVETLANA FEDORENKO1 RAFAEL MENDES2 MARK RU¨ MMELI2 3 4 5 LARS GIEBELER2 BRUNO WEISE2 THOMAS GEMMING2 SILVIO DUTZ6 DIANA ZAHN6 ILDUS ISMAEV7 RUSTEM AMIROV8 KIRILL KHOLIN1 ALEXANDRA VOLOSHINA1 ANASTASIYA SAPUNOVA1 SVETLANA SOLOVIEVA1 ASIYA MUSTAFINA1

      1. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan, Russia 420088
      2. Leibniz Institute for Solid State and Materials Research Dresden, P.O. Box 270116, 01171 Dresden, Germany
      3. Soochow Institute for Energy and Materials Innovations, College of Energy, Collaborative Innovation Center of Suzhou Nano Science and Technology, Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Soochow University, Suzhou 215006, China
      4. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
      5. Institute of Environmental Technology, VSˇB-Technical University of Ostrava, 17 Listopadu 15, 708 33 Ostrava, Czech Republic
      6. Institute of Biomedical Engineering and Informatics (BMTI), Technische Universita¨t Ilmenau, Ilmenau, Germany
      7. A.N. Tupolev Kazan Research Technological University, Kazan, Russia 420015
      8. Kazan (Volga Region) Federal University, Kremlyovskaya Str., 18, Kazan, Russia 420008

    • Dates

       
      Published
      22 April 2021
      Manuscript received
      14 November 2019
      Accepted
      5 March 2021

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