• Preparative, mechanistic and tautomeric investigation of 1-phenyl and 1-methyl derivative of 3-methyl-5-pyrazolone

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/133/0040

    • Keywords

       

      pyrazolone; edaravone; tautomer; 1-phenyl-3-methyl-5-pyrazolone; 1,3-dimethyl-5-pyrazolone.

    • Abstract

       

      1-Phenyl and 1-methyl derivative of 3-methyl-5-pyrazolone were prepared quantitatively via ascalable solvent-free reaction of corresponding hydrazine derivative with ethyl acetoacetate. Differentmechanisms have been proposed for the reaction of hydrazine derivatives (methyl or phenyl) with ethylacetoacetate and also the tautomeric aspects of the targeted compounds have been discussed.

    • Graphical Abstract

       

      Synopsis: 13C NMR and quantitative proportional amount of different tautomeric forms of 1,3-dimethyl-5-pyrazolone in DMSO-d6.

    • Author Affiliations

       

      HOSSEIN FAKHRAIAN1 YASER NAFARI

      1. Department of Chemistry, Imam Hossein University, Tehran, Iran
    • Dates

       
  • Journal of Chemical Sciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.