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    • Keywords


      Salicylic acid and microwaves; Organocatalysis; Paal–Knorr reaction; 2,5-dimethylpyrrole.

    • Abstract


      In this study, the viability of a wide range of crystalline aromatic and aliphatic carboxylic acids asorganocatalysts has been investigated for solvent-free Paal–Knorr pyrrole synthesis under microwave activation.Among these potential catalysts, crystalline salicylic acid proved to be a remarkable catalyst becauseits efficiency remained high even under low microwave power irradiation or a shorter reaction time for themodel reaction. The outstanding catalytic activity of salicylic acid allowed the Paal–Knorr cyclocondensationwith a turnover frequency up to 1472 h-1 which is unique in the context of a metal-free homogeneouscatalysis. The attractive feature of this organocatalyst is its assistance in ultrafast pyrrole synthesis with norisk of metal contamination.

    • Graphical Abstract


      Synopsis: A green and expeditious protocol for the synthesis of 2,5-dimethylpyrroles via combination of salicylic acid as catalyst (in its solid state) and microwaves has been introduced.

    • Author Affiliations



      1. Applied Chemicals Synthesis Lab., Chemistry and Chemical Engineering Research Center of Iran, Pajoohesh Blvd., km 17, Karaj Hwy, Tehran 14968-13151, Iran
    • Dates

  • Journal of Chemical Sciences | News

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