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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/133/0038

    • Keywords

       

      Salicylic acid and microwaves; Organocatalysis; Paal–Knorr reaction; 2,5-dimethylpyrrole.

    • Abstract

       

      In this study, the viability of a wide range of crystalline aromatic and aliphatic carboxylic acids asorganocatalysts has been investigated for solvent-free Paal–Knorr pyrrole synthesis under microwave activation.Among these potential catalysts, crystalline salicylic acid proved to be a remarkable catalyst becauseits efficiency remained high even under low microwave power irradiation or a shorter reaction time for themodel reaction. The outstanding catalytic activity of salicylic acid allowed the Paal–Knorr cyclocondensationwith a turnover frequency up to 1472 h-1 which is unique in the context of a metal-free homogeneouscatalysis. The attractive feature of this organocatalyst is its assistance in ultrafast pyrrole synthesis with norisk of metal contamination.

    • Graphical Abstract

       

      Synopsis: A green and expeditious protocol for the synthesis of 2,5-dimethylpyrroles via combination of salicylic acid as catalyst (in its solid state) and microwaves has been introduced.

    • Author Affiliations

       

      KIOUMARS AGHAPOOR1 FARSHID MOHSENZADEH HOSSEIN REZA DARABI HANI SAYAHI

      1. Applied Chemicals Synthesis Lab., Chemistry and Chemical Engineering Research Center of Iran, Pajoohesh Blvd., km 17, Karaj Hwy, Tehran 14968-13151, Iran
    • Dates

       
  • Journal of Chemical Sciences | News

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