• Methanesulfonic anhydride-promoted sustainable synthesis of thioesters from feedstock acids and thiols

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    • Keywords


      Dehydrative thioesterification; S-carbonylation; MSA; MSAA; Mixed anhydride

    • Abstract


      An unprecedented metal-, halogen- and solvent-free, MSAA-promoted S-carbonylation of thiols with feedstock acids has been developed. This new transformation provides an efficient and atom-economic strategy for the synthesis of thioesters in a single operation from readily available and inexpensive starting materials. The reaction avoids the use of expensive and hazardous coupling reagents, bases and generates water as the only by-product, thus making this chemical synthetic process more viable, environment-friendly and contributing towards sustainable chemistry

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    • Author Affiliations



      1. Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247 667, India
    • Dates

  • Journal of Chemical Sciences | News

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