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      https://www.ias.ac.in/article/fulltext/jcsc/133/0017

    • Keywords

       

      Pyrano-pyrimidine; Ct-DNA; bovine serum; anti-inflammatory; antibacterial

    • Abstract

       

      In this paper, we reported the synthesis of coumarin-pyrimidine derivatives by a four-component reaction involving 4-hydroxycoumarin, aldehyde, thiobarbituric acid and piperidine in ethanol. All the synthesized compounds were well-characterized by IR, NMR and mass spectroscopic techniques. Further, to evaluate the biological potency of the synthesized compounds, initially, DNA cleavage studies were performed. Encouraged by the results obtained from the cleavage studies, the synthesized compounds were screened for in-vitro antibacterial and anti-inflammatory activity. From the biological activity results, it revealed that most of the synthesized compounds were found to exhibit potent antimicrobial and antiinflammatory activity with least IC50 than compared with standard

    • Graphical Abstract

       

    • Author Affiliations

       

      MAMATA DEVENDRA NAIK1 YADAV D BODKE2 J PRASHANTHA3 JAYANTH K NAIK4

      1. Department of P G Studies and Research in Industrial Chemistry, Jnanasahyadri, Kuvempu University,Shankaraghatta, Shivamogga 577451, Karnataka, India
      2. Department of P.G. Studies and Research in Chemistry, Jnanasahyadri, Kuvempu University, Shankaraghatta, Shivamogga 577451, Karnataka, India
      3. Department of P.G. Studies and Research in Microbiology, Jnanasahyadri, Kuvempu University,Shankaraghatta, Shivamogga 577451, Karnataka, India
      4. ITC Life Science and Technology Centre, Bangalore, India
    • Dates

       
  • Journal of Chemical Sciences | News

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