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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/133/0003

    • Keywords

       

      Piperidine; Triazole; Antibacterial activity; Antimycobacterial.

    • Abstract

       

      A novel series of analogues based on 5-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-4-phenyl-2H-1,2,4-triazole-3(4H)-thione core have been synthesized and their potential as antibacterial, antifungal and antitubercular agents was examined. The structure-activity relationship (SAR) studies of these derivatives 5 (a–k) clearly indicate the vital role of lipophilicity as a major factor in enhancing the biological activity of these compounds. Among the compounds screened, 5a, 5c, 5d, 5j and 5k displayed significant activity against Mycobacterium tuberculosis H37Rv strain

    • Graphical Abstract

       

    • Author Affiliations

       

      R RISHIKESAN1 RANJITH P KARUVALAM2 NIBIN JOY MUTHIPEEDIKA3 AYYILIATH M SAJITH4 KOTI REDDY EEDA5 RAJEESH PAKKATH2 KARICKAL R HARIDAS2 VAISHNAV BHASKAR6 KEREYAGALAHALLY H NARASIMHAMURTHY7 A MURALIDHARAN8 9

      1. Department of Chemistry, PG and Research Centre, Sri Paramakalyani College,Alwarkurichi, Tirunelveli 627412, Tamil Nadu, India
      2. School of Chemical Sciences, Kannur University, Payyanur Campus, Edat P.O., Kannur 670327, Kerala,India
      3. Innovation Center for Chemical and Pharmaceutical Technologies, Ural Federal University, 19 Mira Street,Yekaterinburg, Russia 620002
      4. Ortin Laboratories Limited, Hyderabad 500027, Telangana State, India
      5. Department of Chemistry, Vignan’s Foundation for Science and Technology and Research–VFSTR (Deemed to be University), Vadlamudi, Guntur 522213, Andhra Pradesh, India
      6. Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus,Kochi 682041, Kerala, India
      7. Department of Studies in Organic Chemistry, Manasagangotri, University of Mysore,Mysuru 570006, Karnataka, India
      8. Post Graduate and Research Department of Chemistry, Kasargod Govt. College, Kannur University,Kannur, Kerala, India
      9. Organic Chemistry Division, School of Chemical Sciences, Nehru Arts and Science College, Kannur University, Kannur, Kerala, India

    • Dates

       
      Published
      4 February 2021
      Manuscript received
      10 July 2020
      Manuscript revised
      2 November 2020
      Accepted
      6 November 2020

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