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https://www.ias.ac.in/article/fulltext/jcsc/132/0138

Vitamin K3 (Menadione); heterocyclic ring; CUPRAC method; catalase inhibition activity

In this study, derivatives of new vitamin K3 were synthesized by the reactions of 2-methyl-1,4-naphthoquinone 1 with some heterocyclic ring substituted nucleophiles: 1-piperonylpiperazine 2, 1-(2-furoyl)piperazine 5, 1-(2-aminoethyl)piperidine 8, 1-(2-aminoethyl)pyrrolidine 10 and 2,6-dimethyl morpholine 12 in chloroform/triethylamine (TEA) or ethanol at room temperature. Their structures were characterized by Fourier transform infrared spectroscopy (FT-IR), ¹H nuclear magnetic resonance (¹H NMR),attached proton test nuclear magnetic resonance (APT-NMR) and mass spectrometry (MS). Newly synthesizedvitamin K3 derivatives (3, 4, 6, 7, 9, 11, 13, 14) have shown catalase inhibition activity and compound 13 has displayed remarkable potency against catalase enzyme. These compounds were also tested for their antioxidant capacity in vitro by CUPRAC method

NAHIDE GULSAH DENIZ¹ AESHA F SH ABDASSALAM¹ MUSTAFA OZYUREK² EMIN AHMET YESIL³ CIGDEM SAYIL¹

1. Engineering Faculty, Department of Chemistry, Division of Organic Chemistry, Istanbul University-Cerrahpasa, 34320 Avcilar, Istanbul, Turkey
2. Engineering Faculty, Department of Chemistry, Division of Analytical Chemistry, Istanbul University-Cerrahpasa, 34320 Avcilar, Istanbul, Turkey
3. Vocational School, Polymer Technology Programme, Istanbul Gedik University, Pendik, Istanbul, Turkey

Published

8 October 2020

Manuscript received

13 January 2020

Manuscript revised

21 July 2020

Accepted

25 July 2020