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    • Keywords


      One-pot synthesis; Urea derivatives; 2-Amino-3-carbomethoxythiophene; Cytotoxic activity; Docking study

    • Abstract


      An efficient feasible route for the one-pot synthesis of novel series of urea derivatives (2a–2j) from 2-amino-3-carbomethoxythiophene (1) via in situ isocyanate has been developed, and their corresponding anticancer activities were accomplished. The series of urea derivatives were characterized by using 1H, 13C nuclear magnetic resonance and mass spectroscopic analysis. The cytotoxic activities were evaluated against human cervical (HeLa) and human lung (NCI-H23) cancer cell lines. These studies revealed satisfactoryactivity for some of the compounds, which could potentially serve as lead compounds for drug discovery and development. Furthermore, molecular docking studies supported in identifying the potential binding sites between the urea derivatives and eukaryotic ribonucleotidereductase (RR). High ambiguitydriven docking (HADDOCK) modelling was specifically employed to determine the model complex of RR and urea derivatives. The proposed model has provided a deep insight into the molecular level interactions of RR-urea model complexes in understanding the exact pharmacophore for designing highly potent RR inhibitors. Overall, the present work has shed light in developing a feasible and robust approach for the synthesis of novel urea derivatives of 2-amino-3-carbomethoxythiophene and identified a part of molecular structurethat is responsible for a specific biological interaction leading to potential anticancer activities

    • Author Affiliations



      1. Department of Chemistry, GITAM University, Rushikonda, Visakhapatnam, India
      2. Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA
      3. Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur, India
      4. Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan
      5. Department of Chemistry, Gayatri Vidya Parishad College for Degree and PG Courses (A), Rushikonda, Visakhapatnam, India
    • Dates

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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