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      https://www.ias.ac.in/article/fulltext/jcsc/132/0105

    • Keywords

       

      2,3-Tetrasubstituted-2; 3-dihydrobenzofuran-3-carboxamides; Docking, Bcl-2 inhibitor; Bcl-2 inhibitor; chalcones

    • Abstract

       

      Some of the chalcones and flavones are very efficient to facilitate the signal of death to the lung cancer cell through blocking the active site BH3 of Bcl-2 proteins. We designed a number of novel chalcones and flavones targeting the active site of the protein. Docking study showed that the designed compounds were very efficient as the reported compounds. We synthesized and characterized some of the designed compounds.2,3-Tetrasubstituted-2,3-dihydrobenzofuran-3-carboxamides were generated as novel products bybase-catalyzed condensation of o-hydroxyacetophenones and p-nitrobenzaldehyde in different alcohols. Detailed NMR spectroscopic analysis including COSY, homodecoupling and HETCOR (one bond as well aslong-range) studies established the structure of the compounds. Mechanistic paths have been suggested for the formation of the novel products.

    • Author Affiliations

       

      SANKAR P DEY1 NAYIM SEPAY2 ASOK K MALLIK2 AMARENDRA PATRA3

      1. Department of Chemistry, Behala College, Parnashree, Kolkata, West Bengal 700 060, India
      2. Department of Chemistry, Jadavpur University, Kolkata, West Bengal 700 032, India
      3. Department of Chemistry, University College of Science, Calcutta University, Kolkata, West Bengal 700 009, India
    • Dates

       
  • Journal of Chemical Sciences | News

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