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2,3-Tetrasubstituted-2; 3-dihydrobenzofuran-3-carboxamides; Docking, Bcl-2 inhibitor; Bcl-2 inhibitor; chalcones

Some of the chalcones and flavones are very efficient to facilitate the signal of death to the lung cancer cell through blocking the active site BH3 of Bcl-2 proteins. We designed a number of novel chalcones and flavones targeting the active site of the protein. Docking study showed that the designed compounds were very efficient as the reported compounds. We synthesized and characterized some of the designed compounds.2,3-Tetrasubstituted-2,3-dihydrobenzofuran-3-carboxamides were generated as novel products bybase-catalyzed condensation of o-hydroxyacetophenones and p-nitrobenzaldehyde in different alcohols. Detailed NMR spectroscopic analysis including COSY, homodecoupling and HETCOR (one bond as well aslong-range) studies established the structure of the compounds. Mechanistic paths have been suggested for the formation of the novel products.

SANKAR P DEY¹ NAYIM SEPAY² ASOK K MALLIK² AMARENDRA PATRA³

1. Department of Chemistry, Behala College, Parnashree, Kolkata, West Bengal 700 060, India
2. Department of Chemistry, Jadavpur University, Kolkata, West Bengal 700 032, India
3. Department of Chemistry, University College of Science, Calcutta University, Kolkata, West Bengal 700 009, India

Published

11 August 2020

Manuscript received

19 January 2020

Manuscript revised

10 May 2020

Accepted

13 June 2020