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      https://www.ias.ac.in/article/fulltext/jcsc/132/0098

    • Keywords

       

      D-homo androstane lactones; cytotoxicity; NMR analysis; in silico ADME studies.

    • Abstract

       

      New steroidal D-homo androstane derivatives with 5b,6b-epoxy-3,16-dicarbonyl, 6a- and 6bhydroxy-3,16-dicarbonyl and 3b,5a-dihydroxy-6,16-dicarbonyl moieties were synthesized and confirmed by NMR spectroscopy. Novel and starting compounds were evaluated for their potential cytotoxicity in vitro against seven human cancer cell lines (MCF-7, MDA-MB-231, PC3, HeLa, HT-29, A549 and CEM) and one human noncancerous cell line (MRC-5). The most sensitive cell line was MDA-MB-231 derived from female reproductive tissue, wherein all compounds showed moderate to strong cytotoxic activity. Also, new compound with 5b,6b-epoxy-3,16-dicarbonyl moieties showed strong cytotoxic activity against colon adenocarcinoma (HT-29). In this work, in silico ADME properties of novel compounds were assessed by comparing calculated molecular properties with Lipinski, Veber, Egan, Ghose and Muegge criteria

    • Author Affiliations

       

      MARINA P SAVIC1 IVANA Z KUZMINAC1 DUSAN Ð S KORIC1 DIMITAR S JAKIMOV2 LUCIE RAROVA3 MARIJA N SAKAC1 EVGENIJA A DJURENDIC1

      1. Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovic´a 3, 21000 Novi Sad, Serbia
      2. Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia
      3. Laboratory of Growth Regulators, Faculty of Science and Institute of Experimental Botany, Palacky´ University and the Czech Academy of Sciences, S ˇ lechtitelu˚ 27, 78371 Olomouc, Czech Republic
    • Dates

       
  • Journal of Chemical Sciences | News

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