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      https://www.ias.ac.in/article/fulltext/jcsc/132/0096

    • Keywords

       

      Lyconadin-A; 5-bromo-3-nicotinic acid; B-alkyl Suzuki coupling; intramolecular Michael reaction.

    • Abstract

       

      Synthetic efforts toward the synthesis of (?)-lyconadin A are described. B-Alkyl Suzuki coupling is utilized for combining 2-iodo cyclohexenone with the piperidine subunit. The piperidine subunit is derived from 5-bromo-3-nicotinic acid, and iodo cyclohexenone from commercially available (R)-pulegone. An intramolecular Michael reaction is employed for the creation of the C6-C7 bond.

    • Author Affiliations

       

      SATISH KARELLA1 2 SADAGOPAN RAGHAVAN1 2

      1. Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, Telangana 500 007, India
      2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201 002, India

    • Dates

       
      Published
      6 August 2020
      Manuscript received
      4 November 2019
      Manuscript revised
      30 December 2019
      Accepted
      1 January 2020

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      Posted on July 25, 2019

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