• Design and synthesis of novel isatin derivatives as potent analgesic, anti-inflammatory and antimicrobial agents

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    • Keywords

       

      Isatin; thiosemicarbazide; analgesic; anti-inflammatory; antimicrobial activity

    • Abstract

       

      A powerful analgesic, anti-inflammatory and antimicrobial drug was developed by synthesizing a set of new indole-2,3-dione derivatives. The chemical structures of the synthesized derivatives were confirmed by spectroscopic and elemental analyses. Tail flick method, carrageenan-induced foot paw edema technique and agar streak dilution methods were employed to evaluate analgesic, anti-inflammatory and antimicrobial activities (in vitro) of drugs, respectively. In addition, ulcerogenicity of potent derivatives was also estimated. Most of the synthesized derivatives displayed low-to-reasonable ulcer index, with mild-togoodanalgesic, anti-inflammatory and antimicrobial potency. The SARs between the biological activity and differences in the functional group of the title compounds have been explained. 1-(4-Chlorobenzylidene)-4-(4-(1-((dimethylamino)methyl)-5-nitro-2-oxoindolin-3-ylideneamino)phenyl)thiosemicarbazide VIc has beenfound as the potent derivative of this series.

    • Author Affiliations

       

      KOSARAJU LAHARI1 2 RAJA SUNDARARAJAN2

      1. Department of Pharmaceutical Chemistry, MNR College of Pharmacy, Fasalwadi, Sangareddy 502294, Telangana, India
      2. Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM – Deemed to be University, Gandhi Nagar, Rushikonda, Visakhapatnam 530 045, Andhra Pradesh, India
    • Dates

       
  • Journal of Chemical Sciences | News

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