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Schiff base; transition metal complexes; N-alkylation of heterocycles; 1,3-dibromopropane

N-alkylation of heterocycles with 1,3-dibromopropane using Schiff base Co(II), Ni(II), Cu(II) and Zn(II) transition metal complexes as a catalyst was studied in 1:1 and 2:1 coupling ratios under mild conditions. It was observed that all the complexes worked as efficient catalyst with product yield 78–92% for coupling ratio 1:1 and product yield 63–78% for coupling ratio 2:1. N-alkylation of heterocycles with 1,3- dibromopropane in 1:1 coupling ratio is easier with higher yields as compared with N-alkylation in 2:1 coupling ratio.

SUJIT HEGADE¹ YUVRAJ JADHAV¹ SANJAY CHAVAN² GANPATRAO MULIK³ GAUTAM GAIKWAD¹

1. Department of Chemistry, Shrimant Babasaheb Deshmukh Mahavidyalaya (affiliated to Shivaji University, Kolhapur), Atpadi Dist-Sangli, Maharashtra 415301, India
2. Department of Chemistry, Shivaji University, Kolhapur, Maharashtra, India
3. Department of Chemistry, Balwant College (affiliated to Shivaji University, Kolhapur), Vita Dist-Sangli, Maharashtra, India

Published

1 August 2020

Manuscript received

9 January 2020

Manuscript revised

27 March 2020

Accepted

30 March 2020