Design, synthesis and characterization of functionalized pyrazole derivatives bearing amide and sulfonamide moieties from aza-aurones
MOHAMMED CHALKHA MOHAMED BAKHOUCH MOHAMED AKHAZZANE MOHAMED BOURASS YOHANN NICOLAS GHALI AL HOUARI MOHAMED EL YAZIDI
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In this work, we report the synthesis of new pyrazole derivatives bearing amide and sulfonamide frameworks from aza-aurones. Firstly, the intermediate spiropyrazolines were obtained through a highly regioselective 1,3-dipolar cycloaddition of nitrilimines with aza-aurones. Subsequently, the obtainedcycloadducts were subjected to hydrochloric acid in hot ethanol which conducts to 5-(2-aminobenzoyl)-3,4-diaryl-1-phenylpyrazoles. Finally, the target compounds were obtained separately by the action of acetic anhydride, benzoyl chloride and tosyl chloride on the intermediates 2-aminobenzoylpyrazoles, respectively.Structures of all the synthesized compounds were established using IR, 1H NMR and 13C NMR and mass spectroscopy.
MOHAMMED CHALKHA1 MOHAMED BAKHOUCH1 2 MOHAMED AKHAZZANE1 3 MOHAMED BOURASS4 YOHANN NICOLAS4 GHALI AL HOUARI1 MOHAMED EL YAZIDI1
Volume 132, 2020
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