• A robust Co(II)-MOF with nitrogen-rich micropores for CO2 transformation and protective effect on acute heart failure treatment by increasing the expression of Hif-1a

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      https://www.ias.ac.in/article/fulltext/jcsc/132/0085

    • Keywords

       

      MOF; mixed-ligand approach; porous framework; CO2 conversion; acute heart failure.

    • Abstract

       

      A 3D neutral porous MOF (1), [Co2(tdc)2(Hdatz).DMF(H2O)3]n (H2tdc = 2,5-thiophenedicarboxylic acid, Hdatz = 3,5-diamino-1,2,4-triazole), which has aplenty micropores along with free groups of NH2 was assembled via combining 2,5-thiophenedicarboxylic acid ligands and nitrogen-rich 3,5-diamino-1,2,4-triazole as well as Co(II) ion. The activated MOF (1a) has a fine affinity for CO2 molecules and a fine catalytic performance for the conversion of CO2 with internal epoxides along with various terminal ones. Furthermore, the protective activity of 1a on acute heart failure was evaluated by measuring left ventricular ejection fraction and Left ventricular fraction shortening. And the mechanism of this compound was explored by detect the Hif-1a expression level

    • Author Affiliations

       

      WEIWEI SONG1 SHASHA SONG2 XIN FENG1 QIAN YU1 MEI CHEN3

      1. Department of Surgery, Laishan Branch of Yuhuangding Hospital, Yantai, Shandong, China
      2. Department of Emergency, Yuhuangding Hospital, Yantai, Shandong, China
      3. Health Care Division II, Jinan Central Hospital, Jinan, Shandong, China
    • Dates

       
  • Journal of Chemical Sciences | News

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