Highly efficient endo'- selective synthesis of (dispiro 3,2¢- pyrrolidinyl) bisoxindoles containing three contiguous chiral stereocenters with two contiguous quaternary spirostereocenters
PANNEERSELVAM YUVARAJ HUIDROM BIRKUMAR SINGH ARUN PRASATH LINGAM KANDAPALAM DEVARAJAN KATHIRVELAN SANKARANARAYANAN NAGARAJAN
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An efficient, atom economical, one-pot synthesis of endo'- selective (dispiro 3,2¢-pyrrolidinyl) bisoxindole containing three contiguous chiral stereocenters with two contiguous quaternary spirostereo centers have been achieved by three-component reaction of isatins, malononitrile (cyanoacetic ester) and 1,3-dicarbonyl compounds in water in the presence of L-proline. One-pot, azomethine ylide cycloaddition with a dipolarophile without using any catalyst have also been achieved in good yields. This new methodology offers many advantages of catalyst-free, mild reaction conditions, shorter reaction time, environmental friendliness, regio- and stereoselective processes in higher yields
PANNEERSELVAM YUVARAJ1 HUIDROM BIRKUMAR SINGH1 ARUN PRASATH LINGAM KANDAPALAM2 DEVARAJAN KATHIRVELAN3 SANKARANARAYANAN NAGARAJAN4
Volume 132, 2020
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