• Catalyst-free green synthesis of dihydropyrano[2,3-c]pyrazole scaffolds assisted by ethylene glycol (E-G) as a reusable and biodegradable solvent medium

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    • Keywords


      Catalyst-free; ethylene glycol (E-G); green protocol; reusable solvent medium; dihydropyrano[2,3-c]pyrazoles.

    • Abstract


      We revealed a catalyst-free, green and rapid one-pot four-component tandem strategy for the preparation of dihydropyrano[2,3-c]pyrazoles – a biologically significant scaffold – via Knoevenagel-Michael cyclocondensation based on green chemistry principles. Highlights of the current practice are the applicationof non-hazardous reaction circumstances, catalyst-free, operational simplicity, use of inexpensive initiating substances, isolation of pure product via easy filtration thus preventing the requirement for column chromatography, metal-free, excellent yields, time-saving aspects of the reaction. However, the green ethyleneglycol (E-G) can be recycled at least six times with no considerable reduction in activity making it greatly advantageous in addressing the industrial requirements and environmental worries.

    • Author Affiliations



      1. School of Engineering, Apadana Institute of Higher Education, Shiraz, Iran
    • Dates

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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