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Heterocyclic chemistry; 1,3-Hydride transfer; Mechanistic study; Isoindole-fused quinazolinones.

One-pot synthesis of isoindole fused quinazolin 4-ones via intramolecular 1,3 hydride transfer in the presence of acid catalyst has been described. Substrate scope and mechanistic insights were investigated. Substituents on the amide side have a negligible influence on the key step and therefore the method have widescope for accessing various bicyclic core structure.

MOHABUL A MONDAL¹ SUDIPTA MONDAL ABDUL A KHAN

1. Department of Chemistry, Jadavpur University, Kolkata 700 032, West Bengal, India

Published

16 April 2020

Manuscript received

20 June 2019

Manuscript revised

22 November 2019

Accepted

2 January 2020