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1, 2, 3-triazole; Cycloaddition; Xanthine; DPP-4 inhibitory activity

Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. A series of novel 1,2,3-triazole based xanthine derivatives were designed and evaluated for in vitro dipeptidyl peptidase-4 (DPP-4) activity. Among them, the representative compounds 7b, 7e, 7g and 6eshowed excellent inhibitory activity of DPP-4 with IC₅₀ values ranging from 87.41 to 16.34 nM, respectively. The SAR of these xanthine derivatives have been discussed, which would be useful for developing novel DPP-4 inhibitors as treating type 2 diabetes

SIRASSU NARSIMHA^{1 2} KUMARA SWAMY BATTULA² M RAVINDER¹ Y N REDDY³ VASUDEVA REDDY NAGAVELLI²

1. Department of Chemistry, Chaitanya Deemed to be University, Warangal, Telangana 506 001, India
2. Department of Chemistry, Kakatiya University, Warangal, Telangana 506 009, India
3. Department of Pharmacology and Toxicology, Kakatiya University, Warangal, Telangana 506 009, India

Published

24 March 2020

Manuscript received

30 September 2019

Manuscript revised

9 December 2019

Accepted

13 December 2019