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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/132/0059

    • Keywords

       

      1, 2, 3-triazole; Cycloaddition; Xanthine; DPP-4 inhibitory activity

    • Abstract

       

      Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. A series of novel 1,2,3-triazole based xanthine derivatives were designed and evaluated for in vitro dipeptidyl peptidase-4 (DPP-4) activity. Among them, the representative compounds 7b, 7e, 7g and 6eshowed excellent inhibitory activity of DPP-4 with IC50 values ranging from 87.41 to 16.34 nM, respectively. The SAR of these xanthine derivatives have been discussed, which would be useful for developing novel DPP-4 inhibitors as treating type 2 diabetes

    • Author Affiliations

       

      SIRASSU NARSIMHA1 2 KUMARA SWAMY BATTULA2 M RAVINDER1 Y N REDDY3 VASUDEVA REDDY NAGAVELLI2

      1. Department of Chemistry, Chaitanya Deemed to be University, Warangal, Telangana 506 001, India
      2. Department of Chemistry, Kakatiya University, Warangal, Telangana 506 009, India
      3. Department of Pharmacology and Toxicology, Kakatiya University, Warangal, Telangana 506 009, India

    • Dates

       
      Published
      24 March 2020
      Manuscript received
      30 September 2019
      Manuscript revised
      9 December 2019
      Accepted
      13 December 2019

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      Posted on July 25, 2019

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