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C-3 arylation of indoles; meta-functionalized phenols; indole-phenol hybrids; regioselective reaction.

Iodine-mediated highly convenient strategy for the C-3 arylation of indoles with p-quinols is presented. The present work surpasses in forming a C–C bond at the meta-position of the phenols, which is traditionally challenging to functionalize. This protocol further leads the way to have ascendable, forthright access to phenol-assimilated heterocycles which have powerful applications both in synthetic and medicinal chemistry.

NEHA DUA RAMA KRISHNA PEDDINTI¹

1. Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247 667, India

Published

27 February 2020

Manuscript received

14 May 2019

Manuscript revised

21 October 2019

Accepted

4 November 2019