• Carbonyl releasing Schiff base complex of Fe (III): synthesis, physicochemical characterization, antimicrobial and anticancer studies

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      https://www.ias.ac.in/article/fulltext/jcsc/132/0044

    • Keywords

       

      Carbonyl releasing; Schiff base; chelate; anticancer.

    • Abstract

       

      The carbonyl releasing Schiff base chelate derived Fe(III) complex has been synthesized following the simple wet chemical method. The rhombohedral packing of ligands with the metal ion in the complex was confirmed by its XRD pattern and FTIR spectrum. Compounds were characterized by UV-Vis.,PL, FTIR, XRD and TEM techniques. Better biocompatibility of the complex than that of the pure Schiff base had been elaborated on gram-positive and gram-negative bacteria by Agar well disc-diffusion antibacterial screening. The complex also displayed pH-responsive in vitro anticancer therapy on MCF-7 breast cancercells as revealed by MTT assay. The release of CO and Schiff base as well as the interaction of Fe(III) with the mitochondria inside the cell are the key factors of cell biocompatibility. This CORM complex had exhibited higher anticancer activity on MCF-7 cells than the Schiff base and thus potential candidate for thefuture biomedical applications

    • Author Affiliations

       

      R V KUPWADE V J SAWANT1

      1. Department of Chemistry, Smt. Kasturbai Walchand College, Sangli, Maharashtra 416 416, India
    • Dates

       
  • Journal of Chemical Sciences | News

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