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    • Keywords

       

      Reversible and selective detection of Zn2+; Fe2+ as the reversible switch; pH and temperature dependence; DFT and TD-DFT; On-site screening analysis; Cellular imaging

    • Abstract

       

      Temperature-driven, highly sensitive and selective ''TURN-ON'' fluorometric detection of Zn2+ by benzothiazole-based probes (L1 and L2) was reported in physiological pH in the present work. Iron(II) acted as the reversible switch or trigger for the reversible detection of Zn2+ ions by the probes resulting in

      ''TURN-OFF'' fluorescence at room temperature. However, selective detection of Zn2+ in the presence of Fe2+ was irreversible at 0–5 °C. Such temperature dependence on reversible fluorometric detection of Zn2+ in the presence of Fe2+ was explained from the thermodynamic perspective as well as DFT calculations inwhich the absolute enthalpy (H) and Gibbs free energy (G) of the resultant complexes and the fluorophores (L1 and L22) at different temperatures were determined. Enhanced fluorescence of the Zn2+ bound probes wasdue to the inhibition of excited-state intramolecular proton transfer (ESIPT). Effect of solvents, pH, and temperature on the fluorometric detection of Zn2+ was also probed in the present work. The results were translated into the visual detection of Zn2+ on paper-based fluorescence probe and later we demonstrated thesensing of mobile Zn2+ ions by the probes in living HeLa cells as the proof of concept of our present investigations

    • Author Affiliations

       

      DULAL MUSIB1 MD KAUSAR RAZA2 SALAM SUJATA DEVI1 MITHUN ROY1

      1. Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal West, Manipur 795 004, India
      2. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, CV Raman Avenue, Bangalore, Karnataka 560 012, India
    • Dates

       
  • Journal of Chemical Sciences | News

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