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      https://www.ias.ac.in/article/fulltext/jcsc/132/0040

    • Keywords

       

      Coumarin-based TRSMs; Sonochemical MCR; Anthelmintic; Raillietina echinobothrida; Syphacia obvelata; Molecular docking.

    • Abstract

       

      A series of coumarin-based trisubstituted methanes (TRSMs) having uracil scaffold was synthesised employing a green, chromatography-free, and a highly efficient sonochemical multicomponent reaction of diverse aldehydes with 1,3-dimethyl-6-aminouracil and 4-hydroxy-coumarin in the presence of acatalytic amount of DABCO at room temperature and tested their anthelmintic efficacy against helminth parasites, Raillietina echinobothrida and Syphacia obvelata. Some of the TRSMs with substituents in the para position of the phenyl ring showed excellent anthelmintic activity in comparison to the commonly used drugs such as albendazole and praziquantel. The docking study revealed the binding interaction of all the optimizedcompounds with several amino acid residues in the active site of b-tubulin. The compounds showing gooddocking score with b-tubulin showed comparable anthelmintic activity experimentally as well.

    • Author Affiliations

       

      GRACE BASUMATARY1 ERRINI DECRUSE DHAR2 DHARITRI DAS3 RAMESH CH DEKA3 ARUN K YADAV2 GHANASHYAM BEZ1

      1. Department of Chemistry, North-Eastern Hill University, Shillong, Meghalaya 793 022, India
      2. Department of Zoology, North-Eastern Hill University, Shillong, Meghalaya 793 022, India
      3. Department of Chemical Sciences, Tezpur University, Napaam, Tezpur, Assam 784 028, India
    • Dates

       
  • Journal of Chemical Sciences | News

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