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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/132/0036

    • Keywords

       

      Microwave-assisted; multicomponent reaction; green synthesis; one-pot protocol; tetrahydropyridine-3-carboxamides

    • Abstract

       

      A clean, facile and catalyst-free four-component domino reaction of aromatic aldehyde, ethyl cyanoacetate, acetoacetanilide and ammonium acetate in ethanol under microwave irradiation (MWI) conditions is described. Eleven novel and diverse tetrahydropyridine-3-carboxamide derivatives were synthesized in excellent yields (91–97%) using this green protocol. The significant benefits of this method are simple handling, ethanol as solvent, catalyst-free reaction under mild conditions, short reaction times ( less than 10 min) and excellent product yields. Easy workup procedure and simple purification technique of the target molecules evade column chromatography.

    • Author Affiliations

       

      MANDLENKOSI KHUMALO SURYA NARAYANA MADDILA SURESH MADDILA SREEKANTHA B JONNALAGADDA1

      1. School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa
    • Dates

       
  • Journal of Chemical Sciences | News

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