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Deep eutectic solvent; spirooxindoles; eco-friendly; hydrazine; isatin

An efficient and facile synthesis of spirooxindole derivatives bearing pyrano[2,3-c]pyrazole moiety has been achieved using deep eutectic solvent (DES) promoting a four-component reaction. The protocol avoids the use of costly and toxic catalysts and organic solvents which encounters many side effects on the environment and human beings. The simplicity and versatility of this eco-friendly green method isdescribed.

THOKCHOM JEETA DEVI THOKCHOM PRASANTA SINGH OKRAM MUKHERJEE SINGH¹

1. Chemistry Department, Manipur University, Canchipur 795 003, Manipur, India

Published

22 January 2020

Manuscript received

25 July 2019

Manuscript revised

1 October 2019

Accepted

4 October 2019