Novel series of acridone-1,2,3-triazole derivatives: microwave-assisted synthesis, DFT study and antibacterial activities
MOHAMMED AARJANE SIHAM SLASSI BOUCHRA TAZI MOHAMED MAOULOUA AMINA AMINE
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A series of novel acridones bearing a 1,2,3-triazole unit have been synthesized and characterized. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) was performed using both a conventional method and amicrowave-assisted synthetic method. The in vitro antibacterial potencies of all the synthesized compounds were determined against five clinically isolated strains: Escherichia coli, Klebsiella pneumonia, Pseudomonas putida, Serratia marcescens and Staphyloccocus aureus. Furthermore, DFT quantum chemical calculationswere carried out to investigate geometry structures, frontier molecular orbital and gap energies, and molecular electrostatic potential maps (MEP). Lipophilicities of the studied compounds were also determined.
MOHAMMED AARJANE1 SIHAM SLASSI1 BOUCHRA TAZI2 MOHAMED MAOULOUA3 AMINA AMINE1
Volume 135, 2023
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