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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/131/08/0085

    • Keywords

       

      Acridone; 1, 2, 3-triazole; microwave; DFT study; antibacterial activitiy.

    • Abstract

       

      A series of novel acridones bearing a 1,2,3-triazole unit have been synthesized and characterized. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) was performed using both a conventional method and amicrowave-assisted synthetic method. The in vitro antibacterial potencies of all the synthesized compounds were determined against five clinically isolated strains: Escherichia coli, Klebsiella pneumonia, Pseudomonas putida, Serratia marcescens and Staphyloccocus aureus. Furthermore, DFT quantum chemical calculationswere carried out to investigate geometry structures, frontier molecular orbital and gap energies, and molecular electrostatic potential maps (MEP). Lipophilicities of the studied compounds were also determined.

    • Author Affiliations

       

      MOHAMMED AARJANE1 SIHAM SLASSI1 BOUCHRA TAZI2 MOHAMED MAOULOUA3 AMINA AMINE1

      1. LCBAE, CMMBA, Faculty of Science, University Moulay Ismail, BP 11201, Zitoune, Meknes, Morocco
      2. Département des Sciences de Base, Ecole Nationale d’Agriculture, Meknes, Morocco
      3. Medical Microbiology Laboratory, Mohamed V. Hospital, Meknes, Morocco

    • Dates

       
      Published
      August 2019
      Manuscript received
      4 April 2019
      Manuscript revised
      27 May 2019
      Accepted
      28 May 2019

    • Supplementary Material

       

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