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      https://www.ias.ac.in/article/fulltext/jcsc/131/08/0069

    • Keywords

       

      Benzimidazole; benzimidazolium salt; coumarin; cytotoxicity

    • Abstract

       

      Coumarin and benzimidazole derivatives have individual biological activities including anticancer. In this study, we aimed to synthesize coumarin-benzimidazole hybrids in order to investigate their anticancer properties. For this purpose, six 6-substituted-4-chloromethylene coumarin derivatives were synthesized. Sixteen coumarin substituted benzimidazolium chlorides were synthesized by the reaction of 4-chloromethylene coumarin and N-benzylbenzimidazole derivatives. All of the synthesized compounds were characterized by 1H and 13C NMR, IR spectroscopic techniques and elemental analyses. Cytotoxicities of all compounds were testedby [3-(4,5-dimethylthiazole)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay against human prostate (PC-3) and ovarian (A2780) cancer cells. All compounds performed significant cytotoxicities at 100 μMagainst both cancer cell lines. Moreover, some compounds performed significant activities at 1μM against both cancer cell lines and the obtained results suggest that this type of compounds are promising candidates for the treatment of human prostate and ovarian cancers.

    • Author Affiliations

       

      MERT OLGUN KARATAS1 SUAT TEKIN2 BÜLENT ALICI1 SÜLEYMAN SANDAL2

      1. Department of Chemistry, Faculty of Science, ˙Inönü University, 9044280 Malatya, Turkey
      2. Department of Physiology, Faculty of Medicine, ˙Inönü University, 9044280 Malatya, Turkey
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    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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