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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/131/07/0067

    • Keywords

       

      Chiral phase transfer catalysts; enantioselective Michael addition; benzalacetophenone; proline; mandelic acid and tartaric acid.

    • Abstract

       

      Herein, we have explored the enantioselective Michael addition of various malonate esters to benzalacetophenone by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid under mild phase transfer conditions. The obtained results signify that these chiral phasetransfer catalysts are efficacious towards enantioselective Michael addition as the use of it resulted in good enantioselectivity and appreciable chemical yields.

    • Author Affiliations

       

      DEEPAK P MAHAJAN1 HIMANSHU M GODBOLE1 GIRIJ P SINGH1 GAUTHAM G SHENOY2

      1. Lupin Limited, 46 & 47A, Village Nande, Taluka Mulshi, Pune, Maharashtra 412 115, India
      2. Manipal Academy of Higher Education, Manipal, Karnataka 576 104, India

    • Dates

       
      Published
      July 2019
      Manuscript received
      11 February 2019
      Manuscript revised
      6 May 2019
      Accepted
      7 May 2019

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